New Step by Step Map For ceesdekker
New Step by Step Map For ceesdekker
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Nanotechnology presents An array of prospects to add to biology. Here I will present examples in which nanofabrication – the chance to make confined constructions with Proportions at will – is utilised to look at the biophysics of solitary molecules and cells. I'll existing some illustrations from our lab:
Our group research bacterial mobile division and is particularly aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.
, Groningen researchers present the outcomes in their efforts to help make labs more sustainable and provide tips for other labs.
2007, very first serious-time detection of strand exchange in homologous recombination by RecA; discovery of a minimal persistence duration of finishes of microtubules; and settled the system of biosensing with carbon nanotubes
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial at any time research of your dynamics DNA supercoils and the invention of supercoil hopping
Our investigation ranges within the biophysics of DNA to artificial cells and beyond. Remember to have a look below in the spectrum of our present-day initiatives.
We use nanofabricated microfluidic buildings to sample ceesdekker spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which evaluate the elemental role of spatial confinement in the molecular and cellular stage. Our initiatives include things like the subsequent:
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim in the pore is highlighted in pink, as well as a 3D rendering of the motion of the DNA rod is displayed.
Let's say, as opposed to using regular best-down silicon electronics, transistors could be designed from the bottom up working with single organic and natural molecules because the switching features? This idea, which turned the basis of currently’s area of molecular electronics, initially emerged within the nineteen seventies.
Bulk-area coupling identifies the mechanistic connection among Min-protein designs in vivo As well as in vitro
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
Character Physics thanks the nameless reviewers for their contribution to your peer overview of this get the job done.
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2013, controlled shaping of Stay bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations during the handedness of histone tetrasomes